While adding to the addictive gameplay experience, players will also have the ability to obtain special Powerups to complete incredible batting, pitching, and fielding performances. Batting powerups will include the chicken ball, crazy ball, grease ball, bouncy ball, fireball bat and ice bat. Pitching powerups include the super splitter, fireball, dead stop ball, ice ball, iron ball, and ghost ball. Further, fielding power ps include the brick wall, super jump, lightning speed, super dive, super throw, and magnet ball.

See a complete list of all the in-game powerups. 

Unique Interactive Experience: All aspects of the game will be controlled on the Nintendo DS touch screen, including batting, pitching, fielding and baserunning.

Exciting Gameplay Modes: Exhibition mode will allow players to quickly choose their favorite teams so they can immediately jump into the intense baseball action, while Fantasy Pennant mode will offer various tournaments to compete in. All-Star Training will assist players in learning the fundamental DS control functions wrapped up in a variety of fun and challenging mini-games.

All-Star Lineups: Players can create their own unique baseball teams by choosing from the different starting line-ups and putting together their favorite All-Stars.

Uniquely Themed Stadiums: Set in extreme environments that portray the best of North American culture, uniquely themed stadiums are set from the Everglades in Florida to the Frozen North, environments that can only be mastered by the best.

Multiplayer: Supports 2-player DS Wireless and Nintendo Wi-Fi Connection. For added competitiveness, Major League Baseball 2K8 Fantasy All-Stars will utilize DS Wireless and Nintendo Wi-Fi Connections so players can go head-to-head in intense worldwide multiplayer gaming.